Course Descriptions for Electives

The following courses are acceptable electives for graduate students. Other courses may potentially be acceptable with permission of the Graduate Program Director.

Electives for MS and PhD Students

CBE Electives

All graduate students are required to take electives within the Department of Chemical and Biochemical Engineering.

155:513 Fundamentals of Nanoscale Thermodynamics and Transport
Fundamentals of Nanoscale Thermodynamics and Transport (3) Theoretical and multiscale simulation methods bridging macroscopic thermodynamics and continuum transport theories with atomistic quantum mechanics and molecular dynamics. Key theoretical topics include statistical mechanics and thermodynamics of naophases and nanostructured materials, Monte Carlo simulation of nanoscale systems, density functional theory of confined fluids, coarse-grained molecular dynamics and dissipative particle dynamics. The applications include nanoparaticles and nanocomposites, porous materials, nanostructured colloids and surfaces, self-assembled surfactant and polymeric systems, lipid bilayers and cell membranes.

155:531 Biochemical Engineering
Integration of the principles of chemical engineering, biochemistry, and microbiology. Development and application of biochemical engineering principles. Analysis of biochemical and microbial reactions.

16:155:532 Topics in Biochemical Engineering
Advanced course devoted to current topics of interest in biochemical and enzyme engineering. Topics include production, isolation, and purification of enzymes; downstream processing; design and analysis of bioreactors; bioprocess economics; modeling, optimization, and scale-up of biochemical systems. Content and format may vary from year to year.

16:155:533 Bioseparations
Fundamental problems of separation processes important to the recovery of products from biological processes. Topics include membrane filtration centrifugation, chromatography, extraction, electrokinetic methods. Emphasis on protein separations.

16:155:544 Pharmaceutical Organic Nanotechnology (Drug Delivery)
Applications to designing and optimizing pharmaceutical processes and products.  Production, characterization, and usage of pharmaceutical materials. The relationship between pharmaceutical materials and pharmaceutical products.
Syllabus

16:155:548 Pharmaceutical Regulations and GMP Manufacturing 
This course studies the drug development process in the pharmaceutical industry from discovery through FDA marketing approval, reviewing the overall process and the interrelationships linking various Chemistry, Manufacturing, and Controls (CMC) disciplines. It introduces students to regulations governing the process, including interactions with the FDA, ICH, and other regulatory agencies. This course provides students with an in-depth knowledge of the major challenges facing the global pharmaceutical industry with emphasis on CMC issues. Students will learn various aspects of manufacturing pharmaceutical products under current Good Manufacturing Practice (cGMP), and the government regulations required for obtaining approvals for both investigational and marketing applications of new products. The class emphasizes basic understanding of the pharmaceutical business models, global health authority regulations, and long term planning for manufacturing of products to support both clinical studies and commercialization. 

16:155:549 Advanced Engineering Pharmaceutical Kinetics, Thermodynamics, and Transport Processes (Pharmaceutical Development, Administration and Absorption)

This course discusses the application of engineering science principles to drug product development, drug administration to patients, and drug absorption and elimination in the body. The course discusses challenges in drug product development, pharmacokinetics, pharmacodynamics, pharmacologic activity, drug-target concepts and transport processes in the body. Concepts include routes of administration; fundamentals of drug delivery; kinetics of drug absorption, distribution, metabolism and excretion; clearance concepts; and compartmental and physiological models. Students learn how to apply engineering science principles to model pharmacokinetic processes and interpret pharmacokinetic experiments.

16:155:551 Polymer Science and Engineering l
An introduction to polymers from synthesis to basic properties to structure/properties relationships. Understanding the implications of long chain molecular structures on their often unique set of properties. 
 
16:155:561 Applied Surface Chemsitry ( Emulsion and Nanoemulsion Engineering) 
An introduction to emulsion and nanoemulsion principles and their industrial applications. This course covers aspects of emulsion and nanoemulsion physical chemistry, process engineering, characterization techniques, principles of stability and stabilization, and rheology. Manufacturing processes currently used in the food, beverage, and personal care industries will be explored in detail and illustrated through hands-on laboratory experiments.
 
16:155:571 Sustainable, Renewable & Clean Energy
This course is intended to give mainly but not exclusively an engineering and scientific perspective about conventional energy resources, energy challenges and our endeavors on the development of future, sustainable, clean and renewable energy sources. This course will start by offering an introduction and basic fundamental knowledge and science about available energy resources and fossil fuels. It will follow with the challenges we face related to energy; the current state-of-the-art in energy production; various energy resources and how they work; sustainable methods being developed for generation of various clean and renewable energy sources;and the design and optimization of materials, biomass, chemical products and processes that enable energy conservations. The course will also provide information on new materials/nanomaterials, engineering concepts, and thermochemical, photochemical and electrochemical devices for energy applications. The course will examine the relationship between materials, material designs, energy systems and energy resourcesto address sustainability and clean energy challenges, by providing special emphasis on fundamental roles played by chemical engineering and basic scientific principles.
 
16:155:589 (02) Advanced Materials (Special Problems Env) 
students will learn advanced materials encountered in chemical engineering. First, structures of traditional materials, i.e., metals and ceramics, will be  explained. Then, more recently developed materials, such as polymers, composites,  nanomaterials, and advanced carbon materials, will be covered. Properties are understood in terms of the microstructure of materials. Emphasis is placed on the relationship between the structure (controlled by processing methods) and the properties of advanced materials that are important for chemical engineers.

Life Science Electives

The program continues to recognize the growing importance of biotechnology and increasing role of biology as an enabling science in chemical engineering and strongly recommends that students fulfill a life-science requirement in the MS and PhD programs. The following courses within the CBE program are acceptable as Life Science electives:

16:155:531 Biochemical Engineering
16:155:532 Topics in Biochemical Engineering
16:155:533 Bioseparations
16:155:544 Pharmaceutical Organic Nanotechnology (Drug Delivery)

16:155:549 Advanced Engineering Pharmaceutical Kinetics, Thermodynamics, and Transport Processes (Pharmaceutical Development, Administration and Absorption)

16:115:503 Biochemistry
Structure and functions of biochemical materials including proteins, carbohydrates, nucleic acids, and lipids. Metabolism, including metabolic integration. Information processing and control of gene expression. Computer laboratory in structural biology included.

16:115:511 Molecular Biology & Biochemistry
Structure and function of proteins, nucleic acid structure, catalysis of biochemical reactions, glycolysis, oxidative phosphorylation, photosynthesis, properties of membranes, signal transduction, intermediary metabolism. 

16:125:509 Medical Device Development
The development of medical devices that employ primarily polymeric materials in their construction. Materials selection, feasibility studies, prototype fabrication, functionality testing, prototype final selection, biocompatibility considerations, efficacy testing, sterilization validation, FDA regulatory approaches, writing of IDE, 510(k), and PMAs, device production, and record keeping. Examples used include materials for cardiovascular stents and for noninvasive measurements of tissue mechanical properties.

16:125:582 Nano- and Micro-engineered Biointerfaces
Methods and mechanisms for engineering interfaces on the nano- and micro-scale. Synthesis and fabrication, including: 1) preparing substrates that have nano- and/or micro-scale features; and 2) creating nano- and/or micro-scale substrates. The substrate materials discussed will typically consist of ceramics, polymers, and metals whereas the biological systems will comprise cells, genes, and ligands.

16:125:586 Stem Cell Science And Engineering
The science behind stem cell research, its implications and potential, and the ethical and social issues it raises.

16:125:618 Clinical Practicum
Students are introduced to clinical aspects of biomedical engineering by attending regular grand rounds given by clinical specialists from medical schools and hospitals. Selected demonstrations of clinical procedures with applications of modern technology.

16:148:514 Molecular Biology Of Cells
Fundamentals of the molecular organization and functions of cells.

16:148:519 Cellular And Genetic Mechanisms
Basic cellular constituents and cell and tissue types, cellular processes in the cytoplasm, cell and organellar membranes and the nucleus. Uses of recombinant DNA technology in investigating gene structure and function and in diagnosing genetic diseases of inheritance patterns in humans; genetic loci that underlie human disease.

16:148:530 Human Genetics
Examination of molecular and chromosomal bases for human inherited diseases. Molecular approaches to gene identification, including position cloning and linkage analysis. Role of mutations, evaluation of repetitive sequences in the human genome.

16:148:550 Advanced Developmental Biology
Molecular mechanisms of cell type differentiation and body part specification. Cell-cell interaction, signal transduction during development, morphogenetic gradients, pattern formation, focusing on three experimental organisms: the nematode C. elegans, Drosophila, and the mouse. Genetic experimental approaches will be emphasized.

16:148:556 Systems Histology
Analysis of the microscopic structure of the cells making up the tissues and organs of the body. Normal histological structure, histopathologies that illustrate changes in normal architecture produced by diseases.

16:148:565 Gross And Developmental Anatomy
Study of macroscopic structure of the human body by dissection and other methods with reference to functional mechanisms and changes during development and clinical correlations.

16:160:537 Biophysical Chemistry I
Introduction to the physical chemistry of proteins, nucleic acids, and their complexes. Forces that determine biopolymer structure. Principles of protein and nucleic acid structure. Transitions and interactions of biopolymers.

16:681:502 Molecular Genetics
Prokaryotic and eukaryotic molecular genetics. Bacteria, bacteriophage, yeast, nematodes, Drosophila, plants, and mammals.

16:681:530 Introduction To Molecular Medicine
Application of molecular and cell biology to a wide variety of human diseases; recent advances in understanding basic mechanisms.

16:681:555 Molecular Virology
Detailed consideration of fundamental physical-chemical properties, schemes of classification, genetics, and modes of replication of selected animal viruses.

16:681:585 Cancer Molecular Biology
Emphasis on the molecular, cellular, and genetic bases for cancer. Oncogenes and tumor suppressor genes. Signal transduction and cell cycle control in cancer cells. Metastasis. Diagnosis and therapy. Recent understanding of the molecular basis of selected human cancers. Lectures and critical discussion of the current literature.

16:761:515 Medical Physiology
Human physiology from the molecular to the systems level.  Integration of the systems within the healthy individual. Lectures, small discussion groups, and laboratories in pulmonary and cardiovascular physiology.

Technical Electives

The technical electives are meant to supplement the student’s core knowledge with flexibility for the student to tailor the courses to one’s own educational objectives. Most graduate classes in the life sciences, physical sciences, mathematics and engineering qualify. Approval from the Graduate Director may be requested for technical courses that are not on this list.

Any CBE Graduate Course (16:155:xxx) and any Life Science elective.

16:155:551 Polymer Science and Engineering l
An introduction to polymers from synthesis to basic properties to structure/properties relationships. Understanding the implications of long chain molecular structures on their often unique set of properties. 
 
16:160:509 Organic Chemistry of High Polymers
Introduction to the synthesis and reactions of macromolecules, free-radical polymerization, stereospecific polymerization, and stepwise polymerization.

16:332:503 Programming Finance
Network synthesis of driving point and transfer impedances using Foster, Bott-Duffin, Brune, and Darlington techniques; topological methods for analysis of active and passive networks; flow-graph techniques; state-space formulation of general networks; computer-aided network design.

16:332:573 Data Structures and Algorithms
Programming in C and C++. Data structures and algorithms commonly used in engineering software applications. Stacks, linked lists, queues, sorting, trees, search trees, hashing, heaps, graphs, and graph algorithms. Computation models and complexity.

16:332:594  Solar Cells
Photovoltaic material and devices, efficiency criteria, Schottky barrier, p-n diode, heterojunction and MOS devices, processing technology, concentrator systems, power system designs, and storage.

16:635:525 Properties of Ceramic Surfaces
Surface structure of ceramic materials, absorption, surface diffusion, thin films.

16:635:529 Intro Colloid/Surface Chemistry
Colloid or surface chemistry in solvent-based systems; characterization of colloid systems using direct and indirect methods. Thermodynamic treatments of surfaces, adsorption, and charged interfaces. Structural models incorporating neutral and charged adsorbates; various means of stabilizing and destabilizing colloids.

16:650:606 Microfluidic and Nanofluidic Systems
Topics of current interest in mechanical and aerospace engineering, such as applications of computer-aided intelligence, computer-aided manufacturing, and waves in fluids.

16:960:590 Design of Experiments
Fundamental principles of experimental design; completely randomized variance component designs, randomized blocks, Latin squares, incomplete blocks, partially hierarchic mixed-model experiments, factorial experiments, fractional factorials, response surface exploration.

16:155:571 Sustainable, Renewable & Clean Energy
This course is intended to give mainly but not exclusively an engineering and scientific perspective about conventional energy resources, energy challenges and our endeavors on the development of future, sustainable, clean and renewable energy sources. This course will start by offering an introduction and basic fundamental knowledge and science about available energy resources and fossil fuels. It will follow with the challenges we face related to energy; the current state-of-the-art in energy production; various energy resources and how they work; sustainable methods being developed for generation of various clean and renewable energy sources;and the design and optimization of materials, biomass, chemical products and processes that enable energy conservations. The course will also provide information on new materials/nanomaterials, engineering concepts, and thermochemical, photochemical and electrochemical devices for energy applications. The course will examine the relationship between materials, material designs, energy systems and energy resourcesto address sustainability and clean energy challenges, by providing special emphasis on fundamental roles played by chemical engineering and basic scientific principles.
 
16:155:589 (02) Advanced Materials (Special Problems Env) 
students will learn advanced materials encountered in chemical engineering. First, structures of traditional materials, i.e., metals and ceramics, will be  explained. Then, more recently developed materials, such as polymers, composites,  nanomaterials, and advanced carbon materials, will be covered. Properties are understood in terms of the microstructure of materials. Emphasis is placed on the relationship between the structure (controlled by processing methods) and the properties of advanced materials that are important for chemical engineers.

Electives for ME Students

All core MS/PhD courses: 16:155:501, 16:155:502, 16:155:507, 16:55:511, 16:155:514 (course descriptions found here);16:155:532, 16:155:544 (see above under "CBE Electives"); 16:960:540 (see above under "Technical Electives").

16:155:411 Introduction to Biochemical Engineering
Integration of the principles of chemical engineering, food science, biochemistry, and microbiology with applications to the analysis, control, and development of industrial, biochemical, and biological processes. Quantitative, problem-solving methods emphasized.

16:155:550 Computational Methods for Pharmaceutical Nanomaterials
An introduction to organic nanotechnology and its application to manufacturing drug products, using industrial pharmaceutical examples, including nanoparticle and nanocomposite synthesis.

16:155:551 Polymer Science and Engineering l
An introduction to polymers from synthesis to basic properties to structure/properties relationships. Understanding the implications of long chain molecular structures on their often unique set of properties. 
 
16:155:561 Applied Surface Chemsitry ( Emulsion and Nanoemulsion Engineering) 
An introduction to emulsion and nanoemulsion principles and their industrial applications. This course covers aspects of emulsion and nanoemulsion physical chemistry, process engineering, characterization techniques, principles of stability and stabilization, and rheology. Manufacturing processes currently used in the food, beverage, and personal care industries will be explored in detail and illustrated through hands-on laboratory experiments.
 
16:650:554 Mechanics of Continua (Solid Mechanics I)
Introduction to the fundamental concepts of continuum mechanics, including stress and strain, kinematics, balance laws, and material symmetry. Theories of elasticity, plasticity, fracture, viscoelasticity, and classical fluid dynamics.

16:663:501 Medicinal Chemistry: Research Techniques and Principles
Basic course for students preparing to do research in medicinal chemistry. Information management, computer methods, basic laboratory techniques, and principles of medicinal chemistry.

16:663:502 Principles of Drug Design
Identifying new drug leads, drug absorption and distribution, pharmacomodulation, enzymes and receptors as targets, peptidomimetics, computer-aided drug design, and combinatorial chemistry.

16:663:505 Drugs: Structure and Function
A survey of the major pharmaceutical agents in clinical use. Emphasis on the influence of chemical structure in the elicitation of pharmacological effects.

16:720:507 Advanced Pharmaceutics I
Application of physical-chemical principles to the study and evaluation of pharmaceutical systems: solubility phenomena, equilibria, complexation, phase transitions, and pharmaceutical stability, and the fundamentals of pharmacokinetics.

16:720:509 Advanced Pharmaceutics II
Methods, models, and equations used in pharmacokinetics along with their physicochemical and physiological assumptions and limitations. Graphical computer methods of data analysis and applications of pharmacokinetic-pharmacodynamic modeling of pharmacologic responses in biological systems.

16:720:550 Nanotechnology-based Drug Delivery
Materials and processes for novel drug delivery systems; synthesis of biocompatible nanoparticles for health care; product design, current products, and regulatory issues.

16:137:501 Fundamentals of Intellectual Property
This course provides essential knowledge in Intellectual Property (IP) for science and engineering students who are driven to succeed in inventions or are interested in IP strategies or patent related professions.  The course covers the basic and practical aspects of intellectual property with an emphasis on innovation and entrepreneurship, patent creation process, patent classification, prior art searches, and patent portfolio strategic management.

16:137:510 Drug Development from Concept to Market
This course offers an industry overview and orientation to the developmental process of small molecule and biological pharmaceutical products. Sessions include experts in the pharmaceutical industry who discuss their roles in the developmental pipeline. An interactive team-based study format is used to understand how drugs are developed for FDA approval. Topics include target identification and methods of drug discovery, preclinical studies, regulatory applications, patents and licensing, clinical trials, regulatory approvals and marketing processes. Student teams investigate the economics, as well as the biological basis, of major therapeutic areas along with the mechanisms of action, pharmacological properties, and marketing strategies of specific FDA approved drugs. Profiles of scientists working in a biotechnology environment are presented in the final weeks of the course.

16:137:511 Drug Discovery through Preclinical Development
Drug Discovery Through Preclinical Development offers an in-depth look at the discovery, design, and development in the preclinical phase (up to the IND application and entry into humans) of small molecule and biologic drugs. Focusing on concepts, the course is a combination of instructor-led classroom lectures and a series of guest lectures on special topics by scientists, clinicians and managers from industry. 

An important part of this course is student participation in a series of four group presentations on a target or drug of the student’s choosing, starting with target selection and validation, continuing with lead generation and optimization and preclinical phase development studies, and ending with a phase 1 clinical proposal. 

In addition to target biology, lead generation/optimization and drug metabolism-pharmacokinetics, some of the topics covered in this course are: use of genomics in target selection and validation; biologic drugs and the use of bioinformatics; structural biology and molecular modeling in drug design and optimization; translational medicine; phase I clinical trial planning, including use of biomarkers, patient stratification, and proof-of-concept studies; scaling up small molecule synthesis – issues in process development; general aspects of animal models and a discussion of stroke and multiple sclerosis models; aging related disorders, including disorders of the circadian rhythm; addressing reasons for phase 3 failures early in the program.   

Other timely special topics include: new drugs targeting HCV; the mechanisms of bacterial, viral and tumor resistance to drugs; and managing pharma-university alliances. Some topics will be assigned as self-study (for e.g. GLP, maintaining notebooks; some disease animal models).

16:137:580 Practical Aspects of Clinical Trial Design/Conduct
This course will coverfundamental concepts pertaining to the design, analysis and interpretation ofclinical research studies. A fundamental distinction inevidence-based medicine is between observational studies and randomized controlled trials. A randomized controlled trial is the study design that can provide the mostcompelling evidence that the study treatment causes the expected effect onhuman health. In this course, students will learn to design randomizedcontrolled trials. 

16:137:581 Statistics in Clinical and Translational Research
Basic statistical terms and concepts will be presented. The field of pharmaco-epidemiology, which uses epidemiologic methods to examine the benefits or risks of medications in the population will be presented. Students will learn about the basic statistical procedures used to analyze data and be able to apply these techniques utilizing a standard statistical package.They will gain an appreciation of the concepts of random variation and bias.Students will have the opportunity to learn about a wide range of applications of bio-statistical methods to problems in medicine and public health and to recognize pitfalls in interpreting biomedical and public health data.

16:540:530 Forecasting and Time Series Analysis
Alternate linear and nonlinear, stationary and nonstationary time-series models for purposes of prediction. Smoothing techniques, estimating trend and seasonality, multivariate time series, and state-space models. Various estimation and forecasting techniques.

16:540:555 Simulation of Production Systems
Discrete event simulation applied to problems in manufacturing, inventory control, and engineering economics. Topics include simulation languages, estimating production system operating characteristics, comparing alternative systems, and validating approximate analytical models.  

16:540:560 Production Analysis
Analysis of production engineering, with emphasis on planning and control of manufacturing and service systems.

16:540:572 Manufacturing Processes and Control
Overview of manufacturing processes and computer numerically controlled machines, basic digital control theory, design and simulation of advanced controllers, tracking control in machine tools, precision engineering, sensors-based advanced monitoring of machine systems.

16:540:580 Quality Management
Quality management philosophies, Deming, Juran; quality planning, control, and improvement; quality systems, management organizations for quality assurance. Role of operations research.

16:540:585 System Reliability Engineering I
Methods of measuring the reliability and effectiveness of complex engineering systems, including optimization theory, preventive maintenance models, and statistical analysis.

16:540:586 Maintenance Modeling and Optimization
aintenance issues; technical foundations for modeling such large-scale systems; approaches for condition maintenance; and optimization methodologies for optimum inspection, repair, and maintenance schedules.

16:540:595 Software Reliability I
Software-reliability issues; software errors, faults, and failures; software design for reliability; data collection; formal methods for reliability; software fault tolerance; modeling growth in software reliability; cost modeling and estimation; and software quality management.

16:540:685 System Reliability Engineering II
Advanced topics in reliability theory and engineering; availability models of multistate devices; theory of preventive maintenance, replacement, and inspection; accelerated life reliability models.

16:960:540 Statistical Quality Control I
Construction and analysis of control charts for variables and attributes; histogram analysis; use and evaluation of Dodge-Romig and Military Standards acceptance sampling plans.

16:960:542 Life Data Analysis
Statistical methodology for survival and reliability data. Topics include life-table techniques; competing risk analysis; parametric and nonparametric inferences of lifetime distributions; regressions and censored data; Poisson and renewal processes; multistate survival models and goodness-of-fit test. Statistical software used.

16:960:580 Basic Probability
Discrete-probability spaces; combinatorial analysis; occupancy and matching problems; basic distributions; probabilities in a continuum; random variables; expectations; distribution functions; conditional probability and independence; coin tossing; weak law of large number; and the deMoivre-Laplace theorem.

22:630:617 Pharmaceutical Marketing Research
Focuses on the marketing research process and steps involved in a marketing research study. Topics include secondary and syndicated research studies, qualitative techniques like focus groups, and quantitative techniques like surveys and experimental design. Data collection and statistical analysis of quantitative data will also be emphasized. Specific pharmaceutical marketing research issues like pricing, promotional effectiveness, patient and physician satisfaction, brand loyalty, pharmacoeconomics, and outcomes research will also be covered. This course will use an industry-specific consulting project model with opportunity to mine industry data.

22:799:607 Supply Chain Management Strategies
This course focuses on the applications of forecasting models and methodologies throughout value chains, for use in business related activities, including operations, sales, marketing and finance.  The course aims to help students understand the significance of data analysis and model selection in business-related decision making and the development of  managerial insights.  Sophisticated techniques for forecasting are developed and illustrated by combining theory, examples, practical applications and case studies.  The course utilizes Microsoft Excel-based ForecastXTM Software for Windows, which is one of the most comprehensive, Excel-based analysis and forecasting tools available on the market.

16:155:571 Sustainable, Renewable & Clean Energy
This course is intended to give mainly but not exclusively an engineering and scientific perspective about conventional energy resources, energy challenges and our endeavors on the development of future, sustainable, clean and renewable energy sources. This course will start by offering an introduction and basic fundamental knowledge and science about available energy resources and fossil fuels. It will follow with the challenges we face related to energy; the current state-of-the-art in energy production; various energy resources and how they work; sustainable methods being developed for generation of various clean and renewable energy sources;and the design and optimization of materials, biomass, chemical products and processes that enable energy conservations. The course will also provide information on new materials/nanomaterials, engineering concepts, and thermochemical, photochemical and electrochemical devices for energy applications. The course will examine the relationship between materials, material designs, energy systems and energy resourcesto address sustainability and clean energy challenges, by providing special emphasis on fundamental roles played by chemical engineering and basic scientific principles.
 
16:155:589 (02) Advanced Materials (Special Problems Env) 
students will learn advanced materials encountered in chemical engineering. First, structures of traditional materials, i.e., metals and ceramics, will be  explained. Then, more recently developed materials, such as polymers, composites,  nanomaterials, and advanced carbon materials, will be covered. Properties are understood in terms of the microstructure of materials. Emphasis is placed on the relationship between the structure (controlled by processing methods) and the properties of advanced materials that are important for chemical engineers.