Research in this area involves developing fundamental physicochemical understanding of biological processes and translating the knowledge into efficient design of therapeutically and industrial important products and processes. This is accomplished by interweaving the fields of molecular cellular biology with principles of physical chemistry and process engineering. Projects carried out in this area include:
- The development of computational systems biology models for discovering, quantifying and interpreting the relationships that characterize biological processes through the interpretation of experimental and computational data along with background biological knowledge.
- The development of systems biology models of inflammation studying the interplay between immune response and biological rhythms
- The development of strategies for reversing the debilitating effects of nerve injury and disease currently hinges on a better understanding of mechanisms by which the neural circuitry is established and maintained in the healthy animal.
- The understanding of the role of matrix, substrate, and growth factor cues on the phenotypic and differentiation behavior of liver cells, hepatocytes, and embryonic stem cells
- The development and application of gene silencing using antisense oligonucleotides and short interfering RNAs. The application of molecular and nanobioengineering approaches to cancer and to other biomedical problems
- The investigation of the intermolecular and interfacial interactions determining the morphology and collective properties of self-assembling heterogeneous biomembranes.
- The development and characterization of cell-interactive biomaterials for accelerated tissue repair and stem cell-based regenerative medicine.
- The development of cell cultures for production of valuable chemicals.
- Develop reagents and novel analytical tools that enable the field of glycobiology and glycoengineering
- Understand the structure-function roles of glycosylation in biological systems
- Develop hybrid chemical and enzymatic methods for synthesis of glycans, glycoproteins, and glycoconjugates for healthcare and advanced biomaterials related applications
Multiscale characterization of multimodal protein-ligand (e.g., glycans) binding interactions with applications ranging from biologics drug discovery to industrial-scale bioseparations
Faculty in Biotechnology and Bioengineering
Androulakis, Buettner, Chundawat, Moghe, Pedersen, Roth, Schuster, Zhang
|Nanoprobes for New Optical Window Imaging of Diseased Lesions / Polymer Therapeutics for Treatment of Vascular and Heart Disease (Prabhas Moghe)||Rhythmic autonomic and endocrine signals align tissue function with external cues. Does the disruption of those rhythms contribute to inflammatory risks and adverse outcome in patients? (Yannis Androulakis)|
Engineer functionalities on the surface of liposome to enable control release of therapeutics (Stavroula Sofou)
Understanding the structure-function relationships of glycosylation in biological systems (Shishir Chundawat)
|Improved vehicles for nucleic acid delivery using novel formulations like Graplons (graft polymer-lipid oligonucleotide nanocomplexes) (Charlie Roth)|