Benjamin Schuster

Benjamin Schuster

Assistant Professor (Starting Jaunary 2019)

Chemical and Biochemical Engineering

Website:

Education

Postdoctoral Fellowship, University of Pennsylvania, 2014-2018
Ph.D., Biomedical Engineering, Johns Hopkins University, 2014
B.S., Biomedical Engineering, University of Minnesota, with high distinction, 2008

Honors

National Institutes of Health NRSA Postdoctoral Fellowship 2016 – 2018
Johns Hopkins Center for Nanomedicine Award for Research Excellence 2014
University of Minnesota Presidential Scholarship 2004 – 2008
University of Minnesota Bentson Family Scholarship 2004 – 2008

Research Interests

 Bio-inspired materials, protein engineering, cellular and molecular bioengineering, synthetic biology, soft matter, membrane-less organelles
 

Selected Publications

Publications
1. Schuster BS, Reed EH, Parthasarathy R, Janke CN, Caldwell RM, Bermudez JG, Ramage H,
Good MC, Hammer DA. Controllable protein phase separation and modular recruitment to form
responsive, membraneless organelles. In press, Nature Communications.
2. Glantz ST, Berlew EE, Jaber Z, Schuster BS, Gardner KH, Chow BY. Directly light-activated
binding of RGS-LOV photoreceptors to anionic membrane phospholipids. Resubmitted, PNAS.
1
3. Caldwell RM, Bermudez JG, Thai D, Aonbangkhen C, Schuster BS, Courtney T, Deiters A, Hammer
DA, Chenoweth DM, Good MC. Optochemical control of protein localization and activity within
cell-like compartments. Biochemistry 2018; 57:2590-2596.
4. Schuster BS, Allan DB, Kays JC, Hanes J, Leheny R. Photoactivatable fluorescent probes reveal
heterogeneous nanoparticle permeation through biological gels at multiple scales. Journal of Controlled
Release 2017; 260:124-133.
5. Schneider CS, Xu Q, Boylan NJ, Chisholm J, Tang B, Schuster BS, Henning A, Ensign LM, Lee
E, Adstamongkonkul P, Simons BW, Wang SS, Gong X, Yu T, Boyle MP, Suk JS, and Hanes J.
Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways
following inhalation. Science Advances 2017; 3(4):e1601556.
6. Chu KK, Mojahed D, Fernandez CM, Li Y, Liu L, Wilsterman EJ, Diephuis B, Birket SE, Bowers H,
Martin Solomon G, Schuster BS, Hanes J, Rowe SM, Tearney GJ. Particle-tracking microrheology
using micro-optical coherence tomography. Biophysical Journal 2016; 111:1053-63.
7. Schuster BS, Ensign LM, Allan DB, Suk JS, Hanes J. Particle tracking in drug and gene delivery
research: state-of-the-art applications and methods. Advanced Drug Delivery Reviews 2015; 91:70-91.
8. Yu T, Chan KW, Anonuevo A, Song X, Schuster BS, Chattopadhyay S, Xu Q, Oskolkov N, Patel
H, Ensign LM, van Zjil PC, McMahon MT, Hanes J. Liposome-based mucus-penetrating particles
(MPP) for mucosal theranostics: demonstration of diamagnetic chemical exchange saturation transfer
(diaCEST) magnetic resonance imaging (MRI). Nanomedicine 2015; 11:401-5.
9. Nance E, Zhang C, Shih TY, Xu Q, Schuster BS, Hanes J. Brain-penetrating nanoparticles improve
paclitaxel efficacy in malignant glioma following local administration. ACS Nano 2014; 8:10655-64.
10. Birket SE, Chu KK, Liu L, Houser GH, Diephuis BJ, Wilsterman EJ, Dierksen G, Mazur M, Shastry
S, Li Y, Watson JD, Smith AT, Schuster BS, Hanes J, Grizzle WE, Sorscher EJ, Tearney GJ, Rowe
SM. A functional anatomic defect of the cystic fibrosis airway. Am J Respir Crit Care Med 2014;
190:421-32.
11. Schuster BS, Kim AJ, Kays JC, Kanzawa MM, Guggino WB, Boyle MP, Rowe SM, Muzyczka N,
Suk JS, Hanes J. Overcoming the cystic fibrosis sputum barrier to leading adeno-associated virus
gene therapy vectors. Molecular Therapy 2014; 22:14841493.
12. Kim AJ, Boylan NJ, Suk JS, Hwangbo M, Yu T, Schuster BS, Cebotaru L, Lesniak WG, Oh JS,
Adstamongkonkul P, Choi AY, Kannan RM, Hanes J. Use of single-site-functionalized PEG dendrons
to prepare gene vectors that penetrate human mucus barriers. Angew Chem Int Ed 2013; 52:3985-8.
13. Schuster BS, Suk JS, Woodworth GF, Hanes J. Nanoparticle di↵usion in respiratory mucus from
humans without lung disease. Biomaterials 2013; 34:3439-46.
14. Langham AA, Khandelia H, Schuster B, Waring AJ, Lehrer RI, Kaznessis YN. Correlation between
simulated physicochemical properties and hemolycity of protegrin-like antimicrobial peptides:
predicting experimental toxicity. Peptides 2008; 29:1085-93.