Charles M. Roth

Professor

Chemical and Biochemical Engineering

Phone:848-445-6686
Email:cmroth@rutgers.edu
Website:Research Webpage

Education

Harvard Medical School

Postdoc

1995-97

Bioengineering

University of Delaware

Ph.D.

1994

Chemical Engineering

University of Pennsylvania

B.S.E.

1989

Chemical Engineering

Honors

2015

Outstanding Engineering Faculty Award, Rutgers University

2013

Fellow, American Institute of Medical and Biological Engineering

2011-2017

Member, NIH Gene and Drug Delivery Study Section

2008

Warren I. Susman Award for Excellence in Teaching

2005

Rutgers FASIP Award for Teaching, Research and Service (ranked first in Department)

2003

NSF Faculty CAREER Award

2002, 2006

Charles & Johanna Busch Biomedical Research Award

2002

Whitaker Foundation Transitional Career Award

2000

Whitaker Foundation Travel Award

1998-99

Harvard Council on Biomedical Engineering Faculty Excellence Fellow

1995-97

NIH Postdoctoral Fellowship

1989-90

Robert L. Pigford Graduate Student Fellowship, University of Delaware

1989

American Chemical Society Scholastic Achievement Award

1988

Delaware Valley AIChE Junior Award

1985-89

Benjamin Franklin Scholar, University of Pennsylvania

Professional Affiliations

Department of Biomedical Engineering
Department of Chemical and Biochemical Engineering

Cancer Institute of New Jersey
Graduate Program in Biochemistry
Graduate Program in Cell and Developmental Biology
New Jersey Center for Biomaterials 

Research Interests

Our research involves the application of molecular and nanobioengineering approaches to cancer, infection, and other biomedical problems. Much of our work centers on the development of technology for efficient delivery of oligonucleotides (antisense or short interfering RNA) for gene silencing and antimicrobial drugs for infection control. Current projects include: (1) aerosolized nanomedicine for lung infections; (2) nanomaterials for antimicrobial drug delivery to wounds; (3) physiologically based pharmacokinetic modeling of nanomedicines.

Selected Publications

  1. Kantamneni H, Zevon M, Donzanti MJ, Zhao X, Sheng Y, Barkund SR, McCabe LH, Banach-Petrosky W, Higgins LM, Ganesan S, Riman RE, Roth CM, Tan M-C, Pierce MC, Ganapathy V, Moghe PV. Surveillance nanotechnology for multi-organ cancer metastases. Nature Biomed. Engr., 2017; 1:993-1003; doi:10.1038/s41551-017-0167-9.
  2. Nusblat LM, Carroll MJ, Roth CM, Cross talk between M2 macrophages and glioma stem cells. Cell Oncol., 2017; 40:471-482; DOI 10.1007/s13402-017-0337-5.
  3. Gu L, Wang N, Nusblat LM, Soskind R, Roth CM, Uhrich KE.  pH-responsive amphiphilic macromolecular carrier for doxorubicin delivery. J. Bioactive Compatible Polymers, 2017; 32:3-16; doi: 10.1177/0883911516643219.
  4. Ganapathy V, Moghe PV, Roth CM. Targeting tumor metastases: drug delivery mechanisms and challenges. J. Control. Rel., 2015; 219:215-223; PMCID: PMC4745901.
  5. Shreiber DI, Moghe PV, Roth CM. Multidisciplinary "Boot Camp" Training in Cellular Bioengineering to Accelerate Research Immersion for REU Participants. Adv. Eng. Educ., 2015; 4(4):1-15; http://advances.asee.org/wp-content/uploads/vol04/issue04/Papers/AEE-16-Shreiber.pdf.
  6. Peddada LY, Garbuzenko OB, Devore DI, Minko T, Roth CM.  Delivery of antisense oligonucleotides using poly(alkylene oxide)-poly(propylacrylic acid) graft copolymers in conjunction with cationic liposomes.  J. Control. Rel., 2014; 194C:103-112; doi: 10.1016/j.jconrel.2014.08.023; PMCID: PMC4573985.
  7. Gu L, Nusblat LM, Tishbi N, Noble SC, Pinson CM, Mintzer E, Roth CM, Uhrich KE.  Cationic amphiphilic macromolecule (CAM)-lipid complexes for efficient siRNA delivery. J. Control. Rel., 2014; 184:28-35; doi: 10.1016/j.jconrel.2014.04.005; PMCID: PMC4090228.
  8. Naczynski DJ, Tan MC, Zevon M, Wall B, Kohl J, Kulesa A, Chen S, Roth CM, Riman RE, Moghe PV. Rare-earth doped nanoparticles as bioactive probes for shortwave infrared in vivo imaging. Nature Commun., 2013; 4:2199; PMCID: PMC3736359.
  9. Mishra S, Vaughn AD, Devore DI, Roth CM. Delivery of sirna silencing Runx2 using a multifunctional polymer-lipid nanoparticle inhibits osteogenesis in a cell culture model of heterotopic ossification.  Integr. Biol., 2012; 4:1498-1507; PMC4534437.
  10. Waite CL, Roth CM. Binding and transport of PAMAM-RGD in a tumor spheroid model: The effect of RGD targeting ligand density.  Biotechnol. Bioeng., 2011; PMCID: PMC3193538.
  11. Hamed SS, Roth CM.  Mathematical modeling to distinguish cell cycle arrest from cell killing in chemotherapeutic concentration response curves.  J. Pharmacokin. Pharmacodyn., 2011; 38:385-403; doi: 10.1007/s10928-011-9199-z.
  12. Yang H, Ierapetritou MG, Roth CM.  Effects of amino acid transport limitations on cultured hepatocytes.  Biophys. Chem., 2010; 152:89-98; http://dx.doi.org/10.1016/j.bpc.2010.08.004.